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Shun Shimohama Selected Research

Chimerin 1

3/2015Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.

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Shun Shimohama Research Topics

Disease

46Alzheimer Disease (Alzheimer's Disease)
04/2022 - 02/2002
21Parkinson Disease (Parkinson's Disease)
01/2017 - 06/2002
9Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2022 - 02/2003
9Neuroblastoma
01/2018 - 11/2002
9Amyloid Plaque
12/2015 - 04/2002
7Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019 - 11/2002
5Myasthenia Gravis
11/2017 - 07/2010
4Multiple Sclerosis
01/2018 - 08/2015
4Dementia (Dementias)
03/2016 - 01/2006
3Cognitive Dysfunction
01/2020 - 01/2006
3Ischemia
10/2006 - 11/2002
2Tauopathies
04/2022 - 06/2007
2Hepatic Encephalopathy
11/2021 - 11/2014
2Muscle Weakness
06/2021 - 12/2016
2Infections
03/2020 - 01/2013
2Glioma (Gliomas)
07/2018 - 05/2004
2Seizures (Absence Seizure)
04/2017 - 01/2015
2Pain (Aches)
12/2016 - 01/2014
2Ataxia (Dyssynergia)
10/2016 - 01/2006
2Astrocytoma (Pilocytic Astrocytoma)
12/2015 - 08/2003
2Inflammation (Inflammations)
12/2015 - 01/2011
2Mitochondrial Diseases (Mitochondrial Disease)
08/2015 - 07/2004
2Memory Disorders (Memory Loss)
01/2013 - 06/2012
1MELAS Syndrome (Syndrome, MELAS)
06/2022
1Optic Neuritis (Retrobulbar Neuritis)
12/2021
1Cardiac Tamponade
09/2021
1Sarcoidosis (Schaumann Disease)
09/2021
1Aspiration Pneumonia
01/2021
1Korsakoff Syndrome (Wernicke-Korsakoff Syndrome)
11/2020
1Ischemic Stroke
04/2020
1Venous Thrombosis (Deep-Vein Thrombosis)
04/2020
1Protein S Deficiency (Deficiency, Protein S)
04/2020
1Arthritis (Polyarthritis)
03/2020
1Spondylitis
03/2020
1Coma (Comas)
03/2020
1Atherosclerosis
07/2018
1Autoimmune Diseases (Autoimmune Disease)
07/2018

Drug/Important Bio-Agent (IBA)

14Amyloid (Amyloid Fibrils)IBA
04/2022 - 03/2010
14Proteins (Proteins, Gene)FDA Link
10/2016 - 02/2002
11Amyloid beta-PeptidesIBA
12/2015 - 04/2002
10Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
04/2022 - 04/2002
8Peptides (Polypeptides)IBA
01/2012 - 04/2002
7Presenilin-1IBA
06/2012 - 04/2003
5AntibodiesIBA
06/2021 - 03/2005
5Cholinergic Agents (Cholinergics)IBA
01/2013 - 04/2002
5Dopamine (Intropin)FDA LinkGeneric
05/2012 - 09/2004
5RotenoneIBA
02/2009 - 11/2002
4Galantamine (Galanthamine)FDA LinkGeneric
12/2019 - 12/2004
4Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2018 - 01/2010
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2017 - 12/2002
4Cadherins (E-Cadherin)IBA
03/2011 - 10/2003
3AntioxidantsIBA
01/2017 - 10/2005
3Neuroprotective AgentsIBA
03/2013 - 02/2003
3HMGB1 Protein (HMG1)IBA
01/2012 - 02/2003
3Glutamic Acid (Glutamate)FDA Link
02/2007 - 11/2002
2mecobalamin (methylcobalamin)IBA
01/2022 - 12/2018
2HLA-DRB1*04 antigenIBA
12/2021 - 01/2016
2HLA-DRB1 Chains (HLA DRB1)IBA
12/2021 - 08/2015
2Leucine (L-Leucine)FDA Link
07/2018 - 01/2015
2Fingolimod Hydrochloride (FTY720)FDA Link
01/2018 - 01/2016
23-(2,4-dimethoxybenzylidene)anabaseineIBA
01/2018 - 03/2013
2Anticonvulsants (Antiepileptic Drugs)IBA
04/2017 - 07/2006
2CytokinesIBA
01/2017 - 12/2015
2Creatine Kinase (Creatine Phosphokinase)IBA
12/2016 - 01/2015
2LigandsIBA
03/2016 - 06/2002
2Proteasome Endopeptidase Complex (Proteasome)IBA
01/2016 - 02/2007
2Valproic Acid (Depakote)FDA LinkGeneric
01/2015 - 07/2006
2Biomarkers (Surrogate Marker)IBA
01/2015 - 01/2014
2Indicators and Reagents (Reagents)IBA
01/2014 - 01/2014
2Oxidopamine (6 Hydroxydopamine)IBA
03/2013 - 03/2005
2Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
06/2012 - 02/2011
2Cholinergic ReceptorsIBA
02/2011 - 01/2004
2alpha-SynucleinIBA
01/2010 - 05/2004
2beta CateninIBA
05/2007 - 07/2006
2CalciumIBA
02/2007 - 07/2006
2Glutathione (Reduced Glutathione)IBA
02/2007 - 10/2005
2Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2006 - 05/2004
2quinone (benzoquinone)IBA
10/2005 - 03/2005
2Type C PhospholipasesIBA
09/2004 - 08/2003
2Flavin-Adenine Dinucleotide (FAD)IBA
02/2004 - 10/2003
1Lactic Acid (Lactate)FDA LinkGeneric
06/2022
1Pyruvic Acid (Pyruvate)IBA
06/2022
1Mitochondrial DNA (mtDNA)IBA
06/2022
1Choline (Choline Chloride)IBA
04/2022
1GlucocorticoidsIBA
09/2021
1GangliosidesIBA
06/2021
1Proton Pump InhibitorsIBA
11/2020
1apixabanIBA
04/2020
1Warfarin (Coumadin)FDA LinkGeneric
04/2020
1Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA
03/2020
1Rheumatoid FactorIBA
03/2020

Therapy/Procedure

14Therapeutics
09/2021 - 06/2002
2Surgical Portasystemic Shunt (Portosystemic Shunt)
11/2021 - 11/2014
2Transplantation
01/2020 - 10/2006
2Cell- and Tissue-Based Therapy (Cell Therapy)
01/2019 - 09/2011
2Aftercare (After-Treatment)
10/2016 - 12/2015
2Bite Force (Occlusal Forces)
09/2012 - 07/2010
1Tracheostomy
01/2022
1Artificial Respiration (Mechanical Ventilation)
01/2021
1Secondary Prevention
04/2020